What is Cyanidin-3-Glucoside (C3G) ?
Cyanidin-3-glucoside (C3G) is an anthocyanin whose water-soluble nutrients are analogs of the plant pigments responsible for blue, red, purple and black coloring amongst fruits and vegetables. C3G is one of the most essential anthocyanins discovered in nature.
C3G is a member of a class of molecules known as GEFs (guanine-nucleotide-exchange factor) necessary for mammalian embryonic development and many cellular functions in adult tissues. C3G participates in regulating functions that require cytoskeletal remodeling such as adhesion, migration, maintenance of cell junctions, neurite growth and vesicle traffic. (Radha V, et al. Biosci Rep. 2011)
C3G is spatially and temporally regulated to act on Ras family GTPases Rap1, Rap2, R-Ras, TC21 and Rho family member TC10. Increased C3G protein levels are associated with differentiation of various cell types, indicating an important role for C3G in cellular differentiation. In signaling pathways, C3G serves functions dependent on catalytic activity as well as protein interaction and can therefore integrate signals necessary for the execution of more than one cellular function. (Radha V, et al. Biosci Rep. 2011)
Additionally, C3G is one of the most bioactive vitamins in its class and one of the maximum clinically researched. ‘Black Carrot C3G’ (Cyanidin-3-Glucoside) has shown to have cancer cell anti-proliferation activity and metabolism, (Netzel et al., 2007) it possess strong radical scavenging, anti-mutagenic activities, and anti-hypertensive effects (Suda et al., 2003; Igarashi, Kimura, & Takenaka, 2000). C3G also shows in vitro anti-hyperglycemic effects (Matsui et al., 2002).
Inside the discussion of high-powered antioxidants, there have traditionally been fundamental contenders: vitamin C and Resveratrol and Alpha Lipoic Acid to name a few. Vast studies have validated that these nutrients supply antioxidant protection towards free radicals, as a consequence helping us live longer and healthier lives. Now comes ‘Black Carrot C3G’, the newest discovery in modern-day, anti-aging Nutraceuticals and Nootropics (Cognitive Enhancers) in which recent research has demonstrated how this powerful element crosses the blood brain barrier.